In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids

被引：4

作者：

Hong, Chanseok ^{[1
]}

Lee, Chongmu ^{[1
]}

机构：

[1] Inha Univ, Dept Mat Sci & Engn, Inchon 402751, South Korea

来源：

LASERS IN MEDICAL SCIENCE | 2014年 / 29卷 / 01期

关键词：

Porous silicon nanoparticles; Photothermotherapy; Near-infrared light; Surfactant; CANCER THERMOTHERAPY; THERAPEUTIC AGENT; NANOPARTICLES; DESTRUCTION; NANOTUBES; GUIDANCE;

D O I：

10.1007/s10103-013-1316-3

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Dimethyl sulfoxide porous silicon (DMSO-PSi) colloid in which DMSO was used as a surfactant suitable for inhibiting the agglomeration of PSi nanoparticles was prepared for use in cancer photothermotherapy. The photothermal effect of the DMSO-PSi colloid was found to be high enough to destroy cancer cells (T = similar to 52 A degrees C). The mean particle size of the PSi nanoparticles in the DMSO-PSi colloid was 67 nm, which is low enough to flow through blood vessels without causing a blockage. The DMSO-PSi colloid in combination with an NIR laser resulted in a cell viability of 5.70 %, which is a sufficiently high cytotoxic effect.

引用

页码：221 / 223

页数：3

共 40 条

[1] In vitro cell tests of pancreatic malignant tumor cells by photothermotherapy based on DMSO porous silicon colloids
Chanseok Hong
Chongmu Lee
Lasers in Medical Science, 2014, 29 : 221 - 223
[2] Synergistic effects of Hyperthermia with Taurolidine (TRD) in malignant tumor cells - in vitro study of pancreatic and colon cancer cell lines
Buchholz, M.
Flier, A.
Chromik, A.
Uhl, W.
ONCOLOGY RESEARCH AND TREATMENT, 2014, 37 : 55 - 55
[3] Comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for cancer cell destruction based on in vitro cell test results
Chongmu Lee
Chanseok Hong
Jungkeun Lee
Mikwon Son
Soon-Sun Hong
Lasers in Medical Science, 2012, 27 : 1001 - 1008
[4] Comparison of oxidized porous silicon with bare porous silicon as a photothermal agent for cancer cell destruction based on in vitro cell test results
Lee, Chongmu
Hong, Chanseok
Lee, Jungkeun
Son, Mikwon
Hong, Soon-Sun
LASERS IN MEDICAL SCIENCE, 2012, 27 (05) : 1001 - 1008
[5] Anti-neoplastic effects of a new derivative of Taurultam (NDTRLT) in malignant tumor cells - in vitro study of pancreatic cancer cell lines
Buchholz, M.
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ONCOLOGY RESEARCH AND TREATMENT, 2014, 37 : 56 - 56
[6] A RARE MALIGNANT OVARIAN MIXED GERM-CELL TUMOR CONTAINING PANCREATIC TISSUE WITH ISLET CELLS
UEDA, G
YAMASAKI, M
INOUE, M
TANAKA, Y
HIRAMATSU, K
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INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY, 1984, 3 (02) : 220 - 231
[7] Porous silicon nanocarriers for dual targeting tumor associated endothelial cells and macrophages in stroma of orthotopic human pancreatic cancers
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Godin, Biana
Oborn, Carol J.
Alexander, Jenolyn F.
Liu, Xuewu
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CANCER LETTERS, 2013, 334 (02) : 319 - 327
[8] Antigen loading of dendritic cells for tumor immunotherapy: Pancreatic carcinoma cell lysates reduce survival of dendritic cells in vitro
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Herten, A
Meskendahl, T
Schnurr, M
Endres, S
Eigler, A
GASTROENTEROLOGY, 2003, 124 (04) : A184 - A184
[9] Tumor cell lysate-pulsed human dendritic cells induce a T-cell response against pancreatic carcinoma cells:: an in vitro model for the assessment of tumor vaccines
Schnurr, M
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Dauer, M
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CANCER RESEARCH, 2001, 61 (17) : 6445 - 6450
[10] Chronic Cadmium Exposure in Vitro Causes Acquisition of Multiple Tumor Cell Characteristics in Human Pancreatic Epithelial Cells
Qu, Wei
Tokar, Erik J.
Kim, Andrew J.
Bell, Matthew W.
Waalkes, Michael P.
ENVIRONMENTAL HEALTH PERSPECTIVES, 2012, 120 (09) : 1265 - 1271

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