Interpretation of C-Reactive Protein Concentrations in Critically Ill Patients

被引：101

作者：

Lelubre, Christophe ^{[1
,2
]}

Anselin, Sophie ^{[1
]}

Boudjeltia, Karim Zouaoui ^{[2
]}

Biston, Patrick ^{[1
]}

Piagnerelli, Michael ^{[1
,2
]}

机构：

[1] Univ Libre Bruxelles, CHU Charleroi, Dept Intens Care, B-6000 Charleroi, Belgium

[2] CHU Charleroi, Expt Med Lab, ULB Unit 222, B-6110 Montignies le Tilleul, Belgium

来源：

BIOMED RESEARCH INTERNATIONAL | 2013年 / 2013卷

关键词：

COMMUNITY-ACQUIRED PNEUMONIA; INTENSIVE-CARE UNITS; OXIDE SYNTHASE EXPRESSION; ANTIMICROBIAL THERAPY; ENDOTHELIAL FUNCTION; PROMOTES APOPTOSIS; ANTIBIOTIC-THERAPY; SEVERE SEPSIS; SERUM-LEVELS; SOFA SCORE;

D O I：

10.1155/2013/124021

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Infection is often difficult to recognize in critically ill patients because of the marked coexisting inflammatory process. Lack of early recognition prevents timely resuscitation and effective antimicrobial therapy, resulting in increased morbidity and mortality. Measurement of a biomarker, such as C-reactive protein (CRP) concentration, in addition to history and physical signs, could facilitate diagnosis. Although frequently measured in clinical practice, few studies have reported on the pathophysiological role of this biomarker and its predictive value in critically ill patients. In this review, we discuss the pathophysiological role of CRP and its potential interpretation in the inflammatory processes observed in critically ill patients.

引用

页数：11

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