Residual and Recurrent Gastrointestinal Stromal Tumors With KIT Mutations: Findings at First Follow-Up CT After Imatinib Treatment

被引：3
|
作者：
Choi, Dongil [1 ,2 ]
Yoo, Eun Young [1 ,2 ]
Kim, Kyoung-Mee [3 ]
Sohn, Tae Sung [4 ]
Lee, Won Jae [1 ,2 ]
Lee, Ji Young [1 ,2 ]
Chang, Ilsoo [1 ,2 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Dept Radiol, Kangnam Ku, Seoul 135710, South Korea
[2] Sungkyunkwan Univ, Sch Med, Ctr Imaging Sci, Kangnam Ku, Seoul 135710, South Korea
[3] Sungkyunkwan Univ, Sch Med, Dept Pathol, Samsung Med Ctr, Seoul, South Korea
[4] Sungkyunkwan Univ, Sch Med, Dept Surg, Samsung Med Ctr, Seoul, South Korea
来源：
AMERICAN JOURNAL OF ROENTGENOLOGY | 2009年 / 193卷 / 02期
关键词：
cystic change; follow-up CT; gastrointestinal stromal tumor; GIST; imatinib treatment; KIT mutation; POSITRON-EMISSION-TOMOGRAPHY; TYROSINE KINASE; POOR-PROGNOSIS; CYSTIC CHANGES; MESYLATE; INHIBITION; METASTASES; RESISTANCE; DELETIONS; BIOLOGY;
D O I：
10.2214/AJR.08.2106
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
OBJECTIVE. The purpose of this study was to correlate findings on the first follow-up CT after treatment with imatinib in patients with residual or recurrent gastrointestinal stromal tumors (GISTs) with the different types of KIT mutation present at initial resection. CONCLUSION. Residual and recurrent GISTs with KIT mutation of exon 11 deletion more frequently showed both tumor shrinkage and cystic change on 2-month follow-up CT images after the start of imatinib treatment than did other mutation types.
引用
收藏
页码：W100 / W105
页数：6
相关论文
共 50 条
  • [41] Long-Term Imatinib Treatment for Patients with Unresectable or Recurrent Gastrointestinal Stromal Tumors
    Ogata, Kyoichi
    Kimura, Akiharu
    Nakazawa, Nobuhiro
    Suzuki, Masaki
    Yanoma, Toru
    Ubukata, Yasunari
    Iwamatsu, Kiyohito
    Kogure, Norimichi
    Yanai, Mitsuhiro
    Kuwano, Hiroyuki
    DIGESTION, 2018, 97 (01) : 20 - 25
  • [42] Up to 6 years follow-up of patients receiving imatinib mesylate (Glivec) to treat unresectable or metastatic gastrointestinal stromal tumors (GISTs)
    Joensuu, H.
    Demetri, G. D.
    Heinrich, M. C.
    Eisenberg, B. L.
    Fletcher, J. A.
    Corless, C. L.
    Fletcher, C. D.
    Blanke, C.
    Heintz, D.
    von Mehren, M.
    EJC SUPPLEMENTS, 2007, 5 (04): : 404 - 404
  • [43] Imatinib Mesylate for Patients with Recurrent or Metastatic Gastrointestinal Stromal Tumors Expressing KIT: A Decade Experience from Taiwan
    Yeh, Chun-Nan
    Chen, Yen-Yang
    Tseng, Jeng-Hwei
    Chen, Jen-Shi
    Chen, Tsung-Wen
    Tsai, Chun-Yi
    Cheng, Chi-Tung
    Jan, Yi-Yin
    Chen, Miin-Fu
    TRANSLATIONAL ONCOLOGY, 2011, 4 (06): : 328 - 335
  • [44] Association between CT imaging features and KIT mutations in small intestinal gastrointestinal stromal tumors
    Yi-qiong Yin
    Chun-juan Liu
    Bo Zhang
    Yue Wen
    Yuan Yin
    Scientific Reports, 9
  • [45] Association between CT imaging features and KIT mutations in small intestinal gastrointestinal stromal tumors
    Yin, Yi-qiong
    Liu, Chun-juan
    Zhang, Bo
    Wen, Yue
    Yin, Yuan
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [46] Long-Term Follow-up After Endoscopic Resection in Patients With Gastric Gastrointestinal Stromal Tumors
    Zhou, Ping-Hong
    Zhang, Yi-Qun
    Yao, Liqing
    Qin, Xin-Yu
    Xu, Mei-Dong
    Chen, Wei-Feng
    Li, Quan-Lin
    GASTROINTESTINAL ENDOSCOPY, 2012, 75 (04) : 495 - 495
  • [47] Identification of M4205-A Highly Selective Inhibitor of KIT Mutations for Treatment of Unresectable Metastatic or Recurrent Gastrointestinal Stromal Tumors
    Blum, Andreas
    Dorsch, Dieter
    Linde, Nina
    Brandstetter, Susanne
    Buchstaller, Hans-Peter
    Busch, Michael
    Glaser, Nina
    Graedler, Ulrich
    Ruff, Aaron
    Petersson, Carl
    Schieferstein, Hanno
    Sherbetjian, Eva
    Esdar, Christina
    JOURNAL OF MEDICINAL CHEMISTRY, 2023, 66 (04) : 2386 - 2395
  • [48] Gastrointestinal stromal tumors: Recommendations on diagnosis, therapy and follow-up care in Austria
    Ploner, Ferdinand
    Zacherl, Johannes
    Wrba, Friedrich
    Laengle, Friedrich
    Bareck, Evelyne
    Eisterer, Wolfgang
    Kuehr, Thomas
    Schima, Wolfgang
    Haefner, Michael
    Brodowicz, Thomas
    WIENER KLINISCHE WOCHENSCHRIFT, 2009, 121 (23-24) : 780 - 790
  • [49] Gastrointestinal stromal tumors: Long-term follow-up by EUS up to 13 years
    Fusaroli, P
    Khodadadian, E
    Vallar, R
    Togliani, T
    Caletti, G
    GASTROINTESTINAL ENDOSCOPY, 2002, 55 (05) : AB252 - AB252
  • [50] Type and Gene Location of KIT Mutations Predict Progression-Free Survival to First-Line Imatinib in Gastrointestinal Stromal Tumors: A Look into the Exon
    Incorvaia, Lorena
    Fanale, Daniele
    Vincenzi, Bruno
    De Luca, Ida
    Bartolotta, Tommaso Vincenzo
    Cannella, Roberto
    Pantuso, Gianni
    Cabibi, Daniela
    Russo, Antonio
    Bazan, Viviana
    Badalamenti, Giuseppe
    CANCERS, 2021, 13 (05) : 1 - 15
12345