Cytomegalovirus encephalitis/retinitis in allogeneic haematopoietic stem cell transplant recipient treated successfully with combination of cidofovir and foscarnet

被引：15
|
作者：
Hubacek, Petr [1 ]
Keslova, Petra [1 ]
Formankova, Renata [1 ]
Pochop, Pavel [2 ]
Cinek, Ondrej [3 ]
Zajac, Miroslav [4 ]
Lochmanova, Jana [5 ,6 ]
Stary, Jan [1 ]
Sedlacek, Petr [1 ]
机构：
[1] Charles Univ Prague, Dept Paediat Haematol & Oncol, Sch Med 2, Motol Univ Hosp, CZ-15006 Prague 5, Czech Republic
[2] Charles Univ Prague, Dept Ophthalmol Children & Adults, Sch Med 2, Motol Univ Hosp, CZ-15006 Prague 5, Czech Republic
[3] Charles Univ Prague, Dept Paediat, Sch Med 2, Motol Univ Hosp, CZ-15006 Prague 5, Czech Republic
[4] Charles Univ Prague, Dept Microbiol, Sch Med 2, Motol Univ Hosp, CZ-15006 Prague 5, Czech Republic
[5] Univ Hosp Brno, Ctr Mol Biol & Gene Therapy, Dept Internal Med, Brno, Czech Republic
[6] Masaryk Univ, Brno, Czech Republic
来源：
PEDIATRIC TRANSPLANTATION | 2009年 / 13卷 / 07期
关键词：
cytomegalovirus; transplantation; ganciclovir resistance; cidofovir; foscarnet; PHARMACOKINETIC PROPERTIES; IMMUNOCOMPROMISED PATIENTS; ANTIVIRAL ACTIVITY; THERAPEUTIC USE; GANCICLOVIR; INFECTION;
D O I：
10.1111/j.1399-3046.2008.01070.x
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
We report an 18-yr-old female patient with repeated CMV reactivations after HSCT treated by several pre-emptive courses of virostatic therapy. Seven months after HSCT, she developed CMV encephalitis/retinitis. Initial therapy with GCV and hyperimmune globulin failed, and later on GCV-resistant strain was detected. Continual increase of CMV DNA in peripheral blood led us to combined therapy with CDV and FCV, which was successful and free of severe renal toxicity. To our best knowlegde, this is the first reported case of successful CMV treatment with a combination of CDV and FCV.
引用
收藏
页码：919 / 922
页数：4
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