A MULTI-COMPONENT ONE-POT SYNTHESIS OF NOVEL (1,3,4-THIADIAZIN-2-YLAMINO)ISOINDOLINE-1,3-DIONES AS ANTIMICROBIAL AGENTS

被引：6
|
作者：
Khidre, Rizk E. [1 ,2 ]
Abdel-Wahab, Bakr F. [3 ]
Awad, Ghada E. A. [4 ]
机构：
[1] Natl Res Ctr, Chem Ind Div, Giza 12622, Egypt
[2] Jazan Univ, Fac Sci, Chem Dept, Jazan, Saudi Arabia
[3] Natl Res Ctr, Appl Organ Chem Dept, Giza 12622, Egypt
[4] Natl Res Ctr, Chem Nat & Microbial Prod, Giza 12622, Egypt
来源：
HETEROCYCLES | 2017年 / 94卷 / 02期
关键词：
STRUCTURE-BASED DESIGN; DERIVATIVES; MOIETY;
D O I：
10.3987/COM-16-13611
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of new (1,3,4-thiadiazin-2-ylamino)isoindoline-1,3-dione derivatives 5, 8, 9, 11a-d, and 13a,b were prepared via one-pot three component reaction of isobenzofuran-1,3-dione 1, thiocarbohydrazide 2 and various alpha-halocarbonyl compounds. The chemical structure of the new compounds was elucidated by spectral analyses and X-ray single crystal technique. The newly synthesized compounds were also evaluated for their in vitro antimicrobial activity, and showed promising results.
引用
收藏
页码：314 / 325
页数：12
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