Breast tumor diagnosis in cytologic aspirates using monoclonal antibodies to keratin 8 and 17

被引：2
|
作者：
Kirjushkina, MS
Tchipysheva, TA
Ermilova, VD
Guelstein, VI
机构：
[1] RUSSIAN ACAD MED SCI,CANC RES CTR,DEPT HUMAN PATHOL,MOSCOW 115478,RUSSIA
[2] RUSSIAN ACAD MED SCI,CANC RES CTR,LAB MECH CARCINOGENESIS,MOSCOW 115478,RUSSIA
来源：
ACTA CYTOLOGICA | 1997年 / 41卷 / 02期
关键词：
breast neoplasms; monoclonal antibodies; aspiration biopsy; keratin;
D O I：
10.1159/000332517
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
OBJECTIVE: To determine the effect of double immunostaining in the differential diagnosis of the benign vs. malignant nature of breast lesions with fine needle aspiration results. STUDY DESIGN: The study group consisted of 26 samples aspirated from patients with borderline breast lesions. RESULTS: Direct immunostaining by means of monoclonal antibodies directed against individual intermediate filament proteins keratin 8 and 17 revealed that the percentage of K8(+)K17(+) cells in material from patients with fibrocystic disease and fibroadenoma significantly exceeded that found in carcinoma specimens. The diagnoses were confirmed histologically. CONCLUSION: The quantitative method applied in the analysis of double-immunostained cytologic aspirates is recommended for the differential diagnosis of the benign vs. malignant nature of breast lesions in borderline cases.
引用
收藏
页码：307 / 312
页数：6
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