PTPN22 Gene Polymorphisms in Pediatric Systemic Lupus Erythematosus

被引：6

作者：

Bahrami, Tayyeb ^{[1
]}

Valilou, Saeed Farajzadeh ^{[1
,2
]}

Sadr, Maryam ^{[3
]}

Soltani, Samaneh ^{[1
]}

Salmaninejad, Arash ^{[4
]}

Soltaninejad, Ehsan ^{[5
]}

Yekaninejad, Mir Saeed ^{[2
]}

Ziaee, Vahid ^{[2
]}

Rezaei, Nima ^{[6
,7
,8
]}

机构：

[1] USERN, Med Genet Network MeGeNe, Tehran, Iran

[2] Univ Tehran Med Sci, Childrens Med Ctr, Tehran, Iran

[3] Univ Tehran Med Sci, Mol Immunol Res Ctr, Childrens Med Ctr, Tehran, Iran

[4] Mashhad Univ Med Sci, Mashhad, Razavi Khorasan, Iran

[5] Birjand Univ Med Sci, Birjand, Iran

[6] Univ Tehran Med Sci, Sch Med, Dept Immunol, Tehran, Iran

[7] Univ Tehran Med Sci, Res Ctr Immunodeficiencies, Childrens Med Ctr, Tehran, Iran

[8] USERN, NIIMA, Tehran, Iran

来源：

FETAL AND PEDIATRIC PATHOLOGY | 2020年 / 39卷 / 01期

关键词：

pediatric systemic lupus erythematosus (PSLE); PTPN22; polymorphisms; genetic susceptibility; Iranian population; SINGLE NUCLEOTIDE POLYMORPHISMS; JUVENILE IDIOPATHIC ARTHRITIS; LYMPHOID TYROSINE PHOSPHATASE; RHEUMATOID-ARTHRITIS; R620W POLYMORPHISM; NONRECEPTOR; 22; ASSOCIATION; SUSCEPTIBILITY; AUTOIMMUNITY; VARIANT;

D O I：

10.1080/15513815.2019.1630873

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective: Pediatric systemic lupus erythematosus (PSLE) is a heterogeneous autoimmune disorder of unknown origin. PTPN22 gene polymorphisms have been associated with SLE in different populations. We investigated the associations of the rs2476601, rs1217414, rs33996649, rs1276457, and rs1310182 SNPs in the PTPN22 gene with PSLE. Materials and methods: 55 PSLE patients and 93 healthy controls were recruited. SNPs were genotyped by the real-time PCR allelic discrimination method. Results: We found that the PTPN22 polymorphisms rs1310182 A allele (p = 0.01, OR = 1.92 95% CI = 1.16-3.18), and rs1310182 AA genotype with (p < 0.001) and rs12760457 TT (p = 0.046) were associated with PSLE. No significant associations were found between other SNPs and PSLE. Conclusions: The PTPN22 rs1310182 A allele and rs1310182 AA genotype were associated with PSLE and may be a possible genetic marker for susceptibility to PSLE. However, further investigation would be required to elucidate the mechanistic role of this association.

引用

页码：13 / 20

页数：8

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