Commonality but Diversity in Cancer Gene Fusions

被引：54
|
作者：
Rabbitts, Terence H. [1 ]
机构：
[1] Univ Leeds, Sect Expt Therapeut, Leeds Inst Mol Med, Leeds LS9 7TF, W Yorkshire, England
来源：
CELL | 2009年 / 137卷 / 03期
基金：
英国医学研究理事会;
关键词：
CHROMOSOMAL TRANSLOCATIONS; ACTIVATING MUTATIONS; PROSTATE-CANCER; LUNG-CANCER; ALK KINASE; LEUKEMIA; NEUROBLASTOMA; IDENTIFICATION; ONCOGENE; BREAST;
D O I：
10.1016/j.cell.2009.04.034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent findings of gene fusions in carcinomas recapitulate the discovery of chromosomal abnormalities in leukemias and sarcomas decades ago. A recurring feature of carcinoma gene fusions, in contrast to those in hematopoietic and mesenchymal malignancies, is that they result in aberrant cell signaling. This may reflect differences in the differentiation programs of these tissues.
引用
收藏
页码：391 / 395
页数：5
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