A new stereoselective route to preparing optically active 2-imino-penam derivatives

被引：0

作者：

Herak, JJ

Vinkovic, M

机构：

来源：

CROATICA CHEMICA ACTA | 1996年 / 69卷 / 04期

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and simple procedure for preparation of (5R,6S)-2-benzylimino-6-bromo-3-isopropylidene-penam 2 and (5R,6S)-2-benzylimino-3-isopropylidene-penam 8 is described. The 2-imino-penam derivatives are prepared by modification of the Cooper reductive rearrangement of 3 alpha-benzylamide of penicillanic acid sulfoxides. The absolute configurations of starting sulfoxides and imino-products are assigned on the basis of H-1-NMR spectroscopic studies and verified by X-ray structure analysis of sulfoxide 3b and imino-penam 8.

引用

页码：1367 / 1376

页数：10

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