Genomic mosaicism in two strains of dengue virus type 3

被引：5
|
作者：
Villabona-Arenas, Christian Julian [1 ]
de Brito, Anderson Fernandes [1 ]
de Andrade Zanotto, Paolo Marinho [1 ]
机构：
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, BR-05508000 Sao Paulo, Brazil
来源：
INFECTION GENETICS AND EVOLUTION | 2013年 / 18卷
基金：
巴西圣保罗研究基金会;
关键词：
Dengue virus type 3; Phylogeny; Recombination; Split decomposition; MULTIPLE SEQUENCE ALIGNMENT; RNA RECOMBINATION; NATURAL-POPULATIONS; GENETIC-RECOMBINATION; AEDES-AEGYPTI; EVOLUTION; IDENTIFICATION; TRANSMISSION; PERSISTENCE; POLIOVIRUS;
D O I：
10.1016/j.meegid.2013.05.012
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Recombination is a significant factor driving genomic evolution, but it is not well understood in Dengue virus. We used phylogenetic methods to search for recombination in 636 Dengue virus type 3 (DENV-3) genomes and unveiled complex recombination patterns in two strains, which appear to be the outcome of recombination between genotype II and genotype I parental DENV-3 lineages. Our findings of genomic mosaic structures suggest that strand switching during RNA synthesis may be involved in the generation of genetic diversity in dengue viruses. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：202 / 212
页数：11
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