THE CYSTEINE PROTEASE CATHEPSIN B IS A KEY DRUG TARGET AND CYSTEINE PROTEASE INHIBITORS ARE POTENTIAL THERAPEUTICS FOR TBI

被引:0
|
作者
Hook, G. R. [1 ]
Yu, J. [2 ,3 ]
Sipes, N. [1 ]
Pierschbacher, M. D. [1 ]
Hook, V [4 ]
Kindy, M. S. [2 ,3 ]
机构
[1] Amer Life Sci Pharmaceut, La Jolla, CA USA
[2] Med Univ S Carolina, Charleston, SC USA
[3] Appl Neurotechnol Inc, Charleston, SC USA
[4] Univ Calif San Diego, La Jolla, CA 92093 USA
关键词
cathepsin B; drug; target; TBI;
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
C2-34
引用
收藏
页码:A88 / A88
页数:1
相关论文
共 50 条
  • [41] Cysteine protease cathepsin B mediates radiation-induced bystander effects
    Yu Peng
    Man Zhang
    Lingjun Zheng
    Qian Liang
    Hanzeng Li
    Jeng-Ting Chen
    Hongyan Guo
    Sawako Yoshina
    Yu-Zen Chen
    Xiang Zhao
    Xiaoqi Wu
    Bin Liu
    Shohei Mitani
    Jau-Song Yu
    Ding Xue
    Nature, 2017, 547 : 458 - 462
  • [42] Cysteine protease cathepsin B mediates radiation-induced bystander effects
    Peng, Yu
    Zhang, Man
    Zheng, Lingjun
    Liang, Qian
    Li, Hanzeng
    Chen, Jeng-Ting
    Guo, Hongyan
    Oshina, Sawako Y.
    Chen, Yu-Zen
    Zhao, Xiang
    Wu, Xiaoqi
    Liu, Bin
    Mitani, Shohei
    Yu, Jau-Song
    Xue, Ding
    NATURE, 2017, 547 (7664) : 458 - +
  • [43] BEYOND SLICING AND DICING: CYSTEINE PROTEASE CATHEPSIN K A NOVEL TARGET FOR CARDIOMETABOLIC DISEASE
    Nair, S.
    CARDIOLOGY, 2017, 137 : 121 - 121
  • [44] 2-cyano-pyrimidines: A new chemotype for inhibitors of the cysteine protease cathepsin K
    Altmann, Eva
    Aichholz, Reiner
    Betschart, Claudia
    Buhl, Thomas
    Green, Jonathan
    Irie, Osamu
    Teno, Naoki
    Lattmann, Rene
    Tintelnot-Blomley, Marina
    Missbach, Martin
    JOURNAL OF MEDICINAL CHEMISTRY, 2007, 50 (04) : 591 - 594
  • [45] Solid-phase synthesis of cyclic alkoxyketones, inhibitors of the cysteine protease cathepsin K
    Fenwick, AE
    Garnier, B
    Gribble, AD
    Ife, RJ
    Rawlings, AD
    Witherington, J
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2001, 11 (02) : 195 - 198
  • [46] Investigating targets of antibacterial cysteine protease inhibitors
    Vogt, LA
    Wolbach, JP
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 229 : U788 - U788
  • [47] Energetic Basis for Optimization of Cysteine Protease Inhibitors
    Minetti, Conceicao A.
    Prokopczyk, Igor M.
    Orozco, Erika V. M.
    Rosini, Fabiana
    Remeta, David P.
    Montanari, Carlos A.
    PROTEIN SCIENCE, 2016, 25 : 168 - 168
  • [48] MECHANISM-BASED CYSTEINE PROTEASE INHIBITORS
    PALMER, JT
    RASNICK, D
    KLAUS, JL
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 210 : 68 - MEDI
  • [49] Synthesis of macrocyclic trypanosomal cysteine protease inhibitors
    Chen, Yen Ting
    Lira, Ricardo
    Hansell, Elizabeth
    McKerrow, James H.
    Roush, William R.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2008, 18 (22) : 5860 - 5863
  • [50] Antimalarial synergy of cysteine and aspartic protease inhibitors
    Semenov, A
    Olson, JE
    Rosenthal, PJ
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (09) : 2254 - 2258