Redefining the role of biomarkers in heart failure trials: expert consensus document

被引：14

作者：

Kramer, Frank ^{[1
]}

Sabbah, Hani N. ^{[2
]}

Januzzi, James J. ^{[3
]}

Zannad, Faiez ^{[4
,5
]}

van Tintelen, J. Peter ^{[6
]}

Schelbert, Erik B. ^{[7
]}

Kim, Raymond J. ^{[8
]}

Milting, Hendrik ^{[9
]}

Vonk, Richardus ^{[10
]}

Neudeck, Brien ^{[11
]}

Clark, Richard ^{[11
]}

Witte, Klaus ^{[12
]}

Dinh, Wilfried ^{[1
]}

Pieske, Burkert ^{[13
,14
,15
]}

Butler, Javed ^{[16
]}

Gheorghiade, Mihai ^{[17
]}

机构：

[1] Bayer AG, Expt Med Cardiovasc Hematol, Aprather Weg 18a, D-42133 Wuppertal, Germany

[2] Henry Ford Hosp, Div Cardiovasc Med, Dept Med, 2799 West Grand Blvd, Detroit, MI 48202 USA

[3] Massachusetts Gen Hosp, Cardiol Div, Baim Inst Clin Res, Clin Trial Design, Boston, MA 02114 USA

[4] Univ Lorraine, Inserm Clin Invest Ctr 1403, CHU Nancy, Inst Lorrain Coeur & Vaisseaux CHU, Nancy, France

[5] Univ Lorraine, Nancy, France

[6] Univ Amsterdam, Acad Med Ctr, Dept Clin Genet, Amsterdam, Netherlands

[7] Univ Pittsburgh, UPMC Cardiovasc Magnet Resonance Ctr, Pittsburgh, PA USA

[8] Duke Univ, Med Ctr, Dept Med, Div Cardiol, Durham, NC 27710 USA

[9] Ruhr Univ, Univ Clin, Heart & Diabet Ctr NRW, Erich & Hanna Klessmann Inst Cardiovasc Res & Dev, Bad Oeynhausen, Germany

[10] BAYER, Res & Clin Sci Stat, Berlin, Germany

[11] Medtron Diagnost, 8200 Coral Sea St,MVC43, Minneapolis, MN 55112 USA

[12] Univ Leeds, Leeds Inst Cardiovasc & Metab Med, Leeds, W Yorkshire, England

[13] Charite, Campus Virchow Klinikum, Dept Internal Med & Cardiol, Augustenburger Pl 1, D-13353 Berlin, Germany

[14] German Heart Ctr Berlin, Dept Internal Med & Cardiol, Augustenburger Pl 1, D-13353 Berlin, Germany

[15] Berlin Inst Hlth, Kapelle Ufer 2, D-10117 Berlin, Germany

[16] SUNY Stony Brook, Hlth Sci Ctr, Div Cardiol, T-16 Room 080, Stony Brook, NY 11794 USA

[17] Northwestern Univ, Feinberg Sch Med, Ctr Cardiovasc Innovat, 201 East Huron,Galter 3-150, Chicago, IL 60611 USA

来源：

HEART FAILURE REVIEWS | 2017年 / 22卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Heart failure; Biomarker; Drug development; Medical device; Imaging; Clinical trial; EXTRACELLULAR VOLUME FRACTION; CARDIOVASCULAR MAGNETIC-RESONANCE; IDIOPATHIC DILATED CARDIOMYOPATHY; RIGHT-VENTRICULAR CARDIOMYOPATHY; REDUCED EJECTION FRACTION; DIFFERENTIATION FACTOR 15; MYOCARDIAL FIBROSIS; DEVICE DIAGNOSTICS; HISTOLOGICAL VALIDATION; DIASTOLIC DYSFUNCTION;

D O I：

10.1007/s10741-017-9608-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Heart failure is a growing cardiovascular disease with significant epidemiological, clinical, and societal implications and represents a high unmet need. Strong efforts are currently underway by academic and industrial researchers to develop novel treatments for heart failure. Biomarkers play an important role in patient selection and monitoring in drug trials and in clinical management. The present review gives an overview of the role of available molecular, imaging, and device-derived digital biomarkers in heart failure drug development and highlights capabilities and limitations of biomarker use in this context.

引用

页码：263 / 277

页数：15

共 50 条

[41] 2021: The American Association for Thoracic Surgery Expert Consensus Document: Coronary artery bypass grafting in patients with ischemic cardiomyopathy and heart failure
Bakaeen, Faisal G.
Gaudino, Mario
Whitman, Glenn
Doenst, Torsten
Ruel, Marc
Taggart, David P.
Stulak, John M.
Benedetto, Umberto
Anyanwu, Anelechi
Chikwe, Joanna
Bozkurt, Biykem
Puskas, John D.
Silvestry, Scott C.
Velazquez, Eric
Slaughter, Mark S.
McCarthy, Patrick M.
Soltesz, Edward G.
Moon, Marc R.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2021, 162 (03): : 829 - +
[42] Reassessing Phase II Heart Failure Clinical Trials Consensus Recommendations
Butler, Javed
Hamo, Carine E.
Udelson, James E.
O'Connor, Christopher
Sabbah, Hani N.
Metra, Marco
Shah, Sanjiv J.
Kitzman, Dalane W.
Teerlink, John R.
Bernstein, Harold S.
Brooks, Gabriel
Depre, Christophe
DeSouza, Mary M.
Dinh, Wilfried
Donovan, Mark
Frische-Danielson, Regina
Frost, Robert J.
Garza, Dahlia
Gohring, Udo-Michael
Hellawell, Jennifer
Hsia, Judith
Ishihara, Shiro
Kay-Mugford, Patricia
Koglin, Joerg
Kozinn, Marc
Larson, Christopher J.
Mayo, Martha
Gan, Li-Ming
Mugnier, Pierrre
Mushonga, Sekayi
Roessig, Lothar
Russo, Cesare
Salsali, Afshin
Satler, Carol
Shi, Victor
Ticho, Barry
van der Laan, Michael
Yancy, Clyde
Stockbridge, Norman
Gheorghiade, Mihai
CIRCULATION-HEART FAILURE, 2017, 10 (04)
[43] ANMCO/SIC Consensus Document: cardiology networks for outpatient heart failure care
Aspromonte, Nadia
Gulizia, Michele Massimo
Di Lenarda, Andrea
Mortara, Andrea
Battistoni, Ilaria
De Maria, Renata
Gabriele, Michele
Iacoviello, Massimo
Navazio, Alessandro
Pini, Daniela
Di Tano, Giuseppe
Marini, Marco
Ricci, Renato Pietro
Alunni, Gianfranco
Radini, Donatella
Metra, Marco
Romeo, Francesco
EUROPEAN HEART JOURNAL SUPPLEMENTS, 2017, 19 (0D) : D89 - D101
[44] Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology
Bayes-Genis, Antoni
Aimo, Alberto
Jhund, Pardeep
Richards, Mark
de Boer, Rudolf A.
Arfsten, Henrike
Fabiani, Iacopo
Lupon, Josep
Anker, Stefan D.
Gonzalez, Arantxa
Castiglione, Vincenzo
Metra, Marco
Mueller, Christian
Nunez, Julio
Rossignol, Patrick
Barison, Andrea
Butler, Javed
Teerlink, John
Filippatos, Gerasimos
Ponikowski, Piotr
Vergaro, Giuseppe
Zannad, Faiez
Seferovic, Petar
Rosano, Giuseppe
Coats, Andrew J. S.
Emdin, Michele
Januzzi, James L.
EUROPEAN JOURNAL OF HEART FAILURE, 2022, 24 (10) : 1767 - 1777
[45] THE PROGNOSTIC ROLE OF BIOMARKERS IN PATIENTS WITH CHRONIC HEART FAILURE
Kurlyanskaya, Ye. K.
Mrochek, A. G.
Denisevich, T. L.
Kolyadka, M. G.
Russkikh, I. I.
KARDIOLOGIYA, 2020, 60 (01) : 16 - 22
[46] Redefining heart failure: The utility of genomics
Donahue, Mark P.
Marchuk, Douglas A.
Rockman, Howard A.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (07) : 1289 - 1298
[47] Natriuretic Peptides as Biomarkers of Treatment Response in Clinical Trials of Heart Failure
Vaduganathan, Muthiah
Claggett, Brian
Packer, Milton
McMurray, John J. V.
Rouleau, Jean L.
Zile, Michael R.
Swedberg, Karl
Solomon, Scott D.
JACC-HEART FAILURE, 2018, 6 (07) : 564 - 569
[48] Redefining Heart Failure in Breast Cancer
Volgman, Annabelle Santos
Brezden-Masley, Christine
Okwuosa, Tochi
JACC: CARDIOONCOLOGY, 2022, 4 (01): : 66 - 68
[49] ACC expert consensus document on coronary artery stents
Holmes, DR
Hirshfeld, J
Faxon, D
Vlietstra, RE
Jacobs, A
King, SB
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1998, 32 (05) : 1471 - 1482
[50] Abridged version of the expert consensus document on arterial stiffness
Laurent S.
Cockcroft J.
Van Bortel L.
Boutouyrie P.
Giannattasio C.
Hayoz D.
Pannier B.
Vlachopoulos C.
Wilkinson I.
Struijker-Boudier H.
Artery Research, 2007, 1 (1) : 2 - 12

← 1 2 3 4 5 →