Gastroprotective effect of essential oil from Croton cajucara Benth. (Euphorbiaceae)

被引：30
|
作者：
Hiruma-Lima, CA
Gracioso, JS
Rodríguez, JA [1 ]
Haun, M
Nunes, DS
Brito, ARMS
机构：
[1] Univ Talca, Inst Biol, Talca, Chile
[2] Fdn Univ Estadual Tocantins, Inst Biol, Porto Nacional, Brazil
[3] Univ Estadual Campinas, Dept Fis, Inst Biol, Campinas, SP, Brazil
[4] Univ Estadual Campinas, Dept Bioquim, Inst Biol, Campinas, SP, Brazil
[5] Fed Univ Para, Dept Quim, BR-66059 Belem, Para, Brazil
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 69卷 / 03期
关键词：
Croton cajucara; Euphorbiaceae; essential oil; antiulcerogenic activity; in vivo and in vitro toxicity;
D O I：
10.1016/S0378-8741(99)00127-0
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The gastroprotective activity of the essential oil from the bark of Croton cajucara Benth (Euphorbiaceae) was assessed in three different models of experimentally induced gastric ulcer in mice. At oral dose of 100 mg/kg the essential oil reduced gastric lesions induced by hypothermic restraint stress and HCl/ethanol significantly. In the HCl/ethanol model a dose-dependent gastroprotective effect was found. Moreover, significant changes in gastric parameters such as pH, secretion rate and total gastric acid were found after intraduodenal administration of essential oil under ligated pylorus (Shay) conditions. The acute toxicity of essential oil was assessed in mice. The LD50 values were 9.3 and 680 mg/kg for oral and intraperitoneal administrations, respectively. The cytotoxicity of essential oil was studied also. A dose-dependent cell viability inhibition was found in V79 fibroblast cell cultures with an IC50 of 22.9 mu g/ml. Our results support the pharmacological study of this essential oil. (C) 2000 Published by Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：229 / 234
页数：6
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