Microwave-Assisted Cobinamide Synthesis

被引：13

作者：

Proinsias, Keith O. ^{[1
]}

Karczewski, Maksymilian ^{[1
]}

Zieeniewska, Anna ^{[1
,2
]}

Gryko, Dorota ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland

[2] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 16期

关键词：

VITAMIN-B12; CYANIDE; DERIVATIVES; COBALAMIN;

D O I：

10.1021/jo501364b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We present a new method for the preparation of cobinamide (CN)(2)Cbi, a vitamin B-12 precursor, that should allow its broader utility. Treatment of vitamin B-12 with only NaCN and heating in a microwave reactor affords (CN)(2)Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)(2)Cbi(c-lactone) synthesis. Treatment of (CN)(2)Cbi with triethanolamine led to (CN)(2)Cbi(c-lactam).

引用

页码：7752 / 7757

页数：6

共 50 条

[21] Microwave-Assisted Synthesis and Reactivity of Porphyrins
Pineiro, Marta
CURRENT ORGANIC SYNTHESIS, 2014, 11 (01) : 89 - 109
[22] Microwave-assisted synthesis of phtalonitriles and phtalocyanines
Csokai, V
Parlagh, G
Grofesik, A
Kubinyi, M
Bitter, I
SYNTHETIC COMMUNICATIONS, 2003, 33 (10) : 1615 - 1621
[23] Microwave-assisted synthesis of photochromic fulgimides
Lee, Wei-Woon Wayne
Gan, Leong-Ming
Loh, Teck-Peng
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 2007, 185 (01) : 106 - 109
[24] Microwave-assisted combustion synthesis of molybdenum
Shariat, MH
Lu, WK
IRANIAN JOURNAL OF SCIENCE AND TECHNOLOGY, 2001, 25 (B1): : 49 - 56
[25] Microwave-assisted synthesis of β-cyclodextrin nanosponges
Qiao, Zongmei
Zhang, Yangqian
Zhang, Yimin
Jingxi Huagong/Fine Chemicals, 2020, 37 (06): : 1171 - 1177
[26] Microwave-assisted and traceless synthesis of imidazoquinoxalinones
Lin, Mei-Jung
Sun, Chung-Ming
JOURNAL OF COMBINATORIAL CHEMISTRY, 2006, 8 (04): : 455 - 458
[27] Microwave-assisted Synthesis of Benzoxazoles Derivatives
Ozil, Musa
Mentese, Emre
CURRENT MICROWAVE CHEMISTRY, 2020, 7 (03) : 183 - 195
[28] Microwave-Assisted Polyester and Polyamide Synthesis
Nakamura, Takashi
Nagahata, Ritsuko
Takeuchi, Kazuhiko
MINI-REVIEWS IN ORGANIC CHEMISTRY, 2011, 8 (03) : 306 - 314
[29] Microwave-assisted Organic Synthesis in Water
Geetanjali
Singh, Ram
CURRENT MICROWAVE CHEMISTRY, 2021, 8 (02) : 117 - 127
[30] Microwave-assisted synthesis of silver nanorods
Fu-Ken Liu
Pei-Wen Huang
Yu-Cheng Chang
Fu-Hsiang Ko
Tieh-Chi Chu
Journal of Materials Research, 2004, 19 : 469 - 473

← 1 2 3 4 5 →