Microwave-Assisted Cobinamide Synthesis

被引：13
|
作者：
Proinsias, Keith O. [1 ]
Karczewski, Maksymilian [1 ]
Zieeniewska, Anna [1 ,2 ]
Gryko, Dorota [1 ]
机构：
[1] Polish Acad Sci, Inst Organ Chem, PL-01224 Warsaw, Poland
[2] Warsaw Univ Technol, Fac Chem, PL-00664 Warsaw, Poland
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 16期
关键词：
VITAMIN-B12; CYANIDE; DERIVATIVES; COBALAMIN;
D O I：
10.1021/jo501364b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We present a new method for the preparation of cobinamide (CN)(2)Cbi, a vitamin B-12 precursor, that should allow its broader utility. Treatment of vitamin B-12 with only NaCN and heating in a microwave reactor affords (CN)(2)Cbi as the sole product. The purification procedure was greatly simplified, allowing for easy isolation of the product in 94% yield. The use of microwave heating proved beneficial also for (CN)(2)Cbi(c-lactone) synthesis. Treatment of (CN)(2)Cbi with triethanolamine led to (CN)(2)Cbi(c-lactam).
引用
收藏
页码：7752 / 7757
页数：6
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