Synthesis and Antimicrobial Activity of Some Derivatives of 5-Substituted Indole Dihydropyrimidines

被引：1

作者：

Heda, L. C. ^{[1
]}

Sharma, Rashmi ^{[1
]}

Pareek, C. ^{[1
]}

Chaudhari, P. B. ^{[1
]}

机构：

[1] SD Govt Coll, Dept Chem, Res Lab, Beawar 305901, Rajasthan, India

来源：

E-JOURNAL OF CHEMISTRY | 2009年 / 6卷 / 03期

关键词：

Substituted indoles; Dihydropyrimidines; Biginelli Reaction; Multicomponent reaction;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

P. Biginelli reported the synthesis of functionalized 3, 4dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 degrees C. These results are promising, showing these compounds are biologically active.

引用

页码：770 / 774

页数：5

共 50 条

[21] FACILE SYNTHESIS OF 5-SUBSTITUTED ARABINOFURANOSYLURACIL DERIVATIVES
SAWAI, H
HAYASHI, H
SEKIGUCHI, S
[J]. CHEMISTRY LETTERS, 1994, (03) : 605 - 606
[22] Facile synthesis of 5-substituted hydantoins and derivatives
Conway, Stuart J.
Murray, Ross G.
[J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2008, 236
[23] Synthesis and functionalisation of 5-substituted neocuproine derivatives
Eggert, JPW
Lüning, U
Näther, C
[J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2005, 2005 (06) : 1107 - 1112
[24] Synthesis of 5-Substituted Indole-2,3-dione
Zhao, Dandan
Wang, Ping
Xu, Tongsheng
Wu, JieLian
Wang, Jiajia
Xu, Shan
[J]. PROCEEDINGS OF THE 2016 4TH INTERNATIONAL CONFERENCE ON MACHINERY, MATERIALS AND COMPUTING TECHNOLOGY, 2016, 60 : 777 - 780
[25] On the Additivity of Molecular Fragment Dipole Moments of 5-Substituted Indole Derivatives
Wilke, Josefin
Wilke, Martin
Brand, Christian
Meerts, W. Leo
Schmitt, Michael
[J]. CHEMPHYSCHEM, 2016, 17 (17) : 2736 - 2743
[26] SYNTHESIS OF 2-SUBSTITUTED AND 5-SUBSTITUTED THIOPHENE DERIVATIVES
GARRIGUES, B
[J]. PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 1990, 53 (1-4): : 75 - 79
[27] PREPARATION AND PROPERTIES OF SOME 5-SUBSTITUTED URACIL DERIVATIVES
JONES, AS
WALKER, RT
[J]. NUCLEIC ACIDS RESEARCH, 1975, : S1 - S4
[28] Synthesis and antimicrobial activity of some indole derivatives containing pyrazoline and benzodiazepine systems
Saundane, AR
Badiger, J
Sharma, PMV
[J]. INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY, 2005, 14 (04) : 331 - 334
[29] PHOSPHONOFORMATE AND PHOSPHONOACETATE DERIVATIVES OF 5-SUBSTITUTED 2'-DEOXYURIDINES - SYNTHESIS AND ANTIVIRAL ACTIVITY
GRIENGL, H
HAYDEN, W
PENN, G
DECLERCQ, E
ROSENWIRTH, B
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (09) : 1831 - 1839
[30] Synthesis and Antibacterial Activity of 3-(Morpholinopyridyl)-5-substituted Isoxazole Derivatives
Du, Guangjian
Chen, Dongliang
Lu, Ruijiong
Wang, Xiaojun
Yan, Ming
[J]. CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2009, 29 (10) : 1575 - 1581

← 1 2 3 4 5 →