Synthesis and Antimicrobial Activity of Some Derivatives of 5-Substituted Indole Dihydropyrimidines

被引：1

作者：

Heda, L. C. ^{[1
]}

Sharma, Rashmi ^{[1
]}

Pareek, C. ^{[1
]}

Chaudhari, P. B. ^{[1
]}

机构：

[1] SD Govt Coll, Dept Chem, Res Lab, Beawar 305901, Rajasthan, India

来源：

E-JOURNAL OF CHEMISTRY | 2009年 / 6卷 / 03期

关键词：

Substituted indoles; Dihydropyrimidines; Biginelli Reaction; Multicomponent reaction;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

P. Biginelli reported the synthesis of functionalized 3, 4dihydropyrimidine-2 (1H)-ones via three component condensation of an aromatic aldehyde, urea and ethylacetoacetate. This multicomponent reaction is of much importance due to excellent pharmacological properties of dihydropyrimidines. In this account, we synthesized some halo substituted indole dihydropyrimidines and evaluated their antimicrobial activity. The minimum inhibitory concentration (MIC) was determined by micro dilution technique in Mueller-Hinton broth. The MICs were recorded after 24 hours of incubation at 37 degrees C. These results are promising, showing these compounds are biologically active.

引用

页码：770 / 774

页数：5

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