GENETIC ENGINEERING Chemical control for CRISPR editing

被引：4
|
作者：
Hilton, Isaac B. [1 ,2 ]
Gersbach, Charles A. [1 ,2 ,3 ]
机构：
[1] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA
[2] Duke Univ, Ctr Genom & Computat Biol, Durham, NC 27706 USA
[3] Duke Univ, Med Ctr, Dept Orthopaed Surg, Durham, NC 27706 USA
来源：
NATURE CHEMICAL BIOLOGY | 2017年 / 13卷 / 01期
基金：
美国国家科学基金会;
关键词：
OFF-TARGET CLEAVAGE; GENOME; SYSTEM;
D O I：
10.1038/nchembio.2243
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New approaches allow tight control over Cas9 activity using chemical induction. These studies expand the ability to rapidly induce and suppress Cas9-mediated nuclease activity and conditionally modulate the multiplex regulation of endogenous gene expression.
引用
收藏
页码：2 / 3
页数：2
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