Recent Advances in Chemical Control of CRISPR/Cas9 Genome Editing Technology

被引：1
|
作者：
Xiao, Heng [1 ,2 ]
Li, Yongkui [2 ]
Xing, Xiwen [1 ]
机构：
[1] Jinan Univ, Coll Life Sci & Technol, Guangzhou 510632, Peoples R China
[2] Jinan Univ, Inst Med Microbiol, Guangzhou 510632, Peoples R China
来源：
CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2023年 / 44卷 / 03期
关键词：
Chemical control; Small molecule; Clustered regularly interspaced short palindromic repeats(CRISPR); CRISPR-associated protein 9(CRISPR; Cas9); Genome editing; TARGETED PROTEIN-DEGRADATION; NUCLEIC-ACID; CONDITIONAL CONTROL; CRISPR-CAS9; SYSTEM; DELIVERY; EFFICIENT; THERAPY; CELLS;
D O I：
10.7503/cjcu20220410
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
As a revolutionary technology in the field of genetic engineering, clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9(CRISPR/Cas9) genome editing contribute significantly to various important diseases, such as cancer, genetic diseases and infectious diseases. However, precisely spatiotemporal control of genome editing in specific cells and tissues to avoid off-target effects is still one of the major challenges for clinical translation of this technology. Recently, using chemical molecules and reactions to control the activity of CRISPR/Cas9 is becoming one of the important means to increase the gene editing efficiency. This review summarized the recent advances about chemical control of CRISPR/Cas9 gene editing and the future applications of these technologies in clinical medicine was proposed.
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页数：9
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