Bacterial persistence

被引：5

作者：

Liu YunXiao ^{[1
]}

Yang Jin ^{[1
]}

Zhao ZhiLun ^{[1
]}

Pu YingYing ^{[1
]}

Bai Fan ^{[1
]}

机构：

[1] Peking Univ, Sch Life Sci, Biodynam Opt Imaging Ctr BIOPIC, Beijing 100871, Peoples R China

来源：

SCIENCE CHINA-CHEMISTRY | 2014年 / 57卷 / 12期

基金：

中国国家自然科学基金;

关键词：

persistence; bacterial survival; bacterial revival; phenotypic heterogeneity; PROGRAMMED CELL-DEATH; C-DI-GMP; ESCHERICHIA-COLI; SOS RESPONSE; PSEUDOMONAS-AERUGINOSA; SINGLE-CELL; ANTIBIOTICS; RESISTANCE; TOLERANCE; INCREASES;

D O I：

10.1007/s11426-014-5245-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Although bacterial persistence was first observed in 1944, its underlying mechanism is just beginning to be understood and many fundamental questions remain. In this review, we summarize studies in order to chart the full map of bacterial persistence. Because persistence significantly contributes to disease recalcitrance, we also elucidate the probable relationships between bacterial persistence and prolonged chronic infections, with some comments on future research directions and therapeutic strategies.

引用

页码：1625 / 1633

页数：9

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