Development of Drug Delivery Systems Based on Layered Hydroxides for Nanomedicine

被引：52

作者：

Barahuie, Farahnaz ^{[1
]}

Hussein, Mohd Zobir ^{[1
]}

Fakurazi, Sharida ^{[2
,3
]}

Zainal, Zulkarnain ^{[1
]}

机构：

[1] Univ Putra Malaysia, Mat Synth & Characterizat Lab, Inst Adv Technol ITMA, Serdang 43400, Malaysia

[2] Univ Putra Malaysia, Inst Biosci, Lab Vaccines & Immunotherapeut, Serdang 43400, Malaysia

[3] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Human Anat, Serdang 43400, Malaysia

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 05期

关键词：

layered hydroxides; nanomedicine; drug delivery; nanocomposite; nanocarrier; LDH; ZLH; cytotoxicity assay; CONVERTING-ENZYME-INHIBITORS; CONTROLLED-RELEASE PROPERTY; IN-VITRO; COMPARATIVE TOXICITY; NANOHYBRID COMPOUND; CELLULAR TOXICITY; SUSTAINED-RELEASE; ANTICANCER DRUG; UREA HYDROLYSIS; CAFFEIC ACID;

D O I：

10.3390/ijms15057750

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Layered hydroxides (LHs) have recently fascinated researchers due to their wide application in various fields. These inorganic nanoparticles, with excellent features as nanocarriers in drug delivery systems, have the potential to play an important role in healthcare. Owing to their outstanding ion-exchange capacity, many organic pharmaceutical drugs have been intercalated into the interlayer galleries of LHs and, consequently, novel nanodrugs or smart drugs may revolutionize in the treatment of diseases. Layered hydroxides, as green nanoreservoirs with sustained drug release and cell targeting properties hold great promise of improving health and prolonging life.

引用

页码：7750 / 7786

页数：37

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