Thulium complex with DOPC as 1H NMR temperature sensor

The goal of the research was to show the limits within which Tm3+ can be used as a linear response probe in lipid membrane. Temperature dependence of lanthanide-induced chemical shifts (LISs) were studied using the example of DOPC phospholipid by means of NMR spectroscopy. It was demonstrated that these dependences have thermal feature, which could be connected with the changes of the structure of lanthanide-phospholipid complex (Tm-DOPC complex). The analysis of paramagnetic properties such as the temperature sensitivity of LIS indicates the prospect of using kinetically unstable lanthanide complexes as shifting temperature-sensitive probes for determining local temperature using MRI technologies.