CAR T therapy extends its reach to autoimmune diseases

被引：19
|
作者：
Baker, Daniel J. [1 ,2 ,3 ,4 ]
June, Carl H. [1 ,2 ,3 ]
机构：
[1] Univ Penn, Ctr Cellular Immunotherapies, Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Univ Penn, Dept Pathol & Lab Med, Perelman Sch Med, Philadelphia, PA 19104 USA
[3] Univ Penn, Parker Inst Canc Immunotherapy, Philadelphia, PA 19104 USA
[4] Univ Penn, Cardiovasc Inst, Perelman Sch Med, Dept Med, Philadelphia, PA 19104 USA
来源：
CELL | 2022年 / 185卷 / 24期
关键词：
D O I：
10.1016/j.cell.2022.10.026
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
CAR T therapy has revolutionized the treatment of hematologic cancers. In their recent Nature Medicine paper, Mackensen et al. report the use of CART cells to treat systemic lupus erythematosus in five patients. This provides enthusiasm to further explore CAR T therapy beyond oncology.
引用
收藏
页码：4471 / 4473
页数：3
相关论文
共 50 条
  • [41] CAR T-cells: New therapeutic opportunities in autoimmune diseases?
    Chou, Mei-Chia
    Lee, Wei-Kai
    Yeh, Wen-Bin
    Yong, Su-Boon
    Li, Chia-Jung
    Chang, Renin
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2023, 26 (08) : 1427 - 1428
  • [42] CAR-Based Therapy for Autoimmune Diseases: A Novel Powerful Option
    Muzes, Gyorgyi
    Sipos, Ferenc
    CELLS, 2023, 12 (11)
  • [43] CAR-T cell therapy embarks on autoimmune disease
    Alexandros Rampotas
    Johanna Richter
    David Isenberg
    Claire Roddie
    Bone Marrow Transplantation, 2025, 60 (1) : 6 - 9
  • [44] Autoimmune disease is the next frontier for CAR T cell therapy
    Carrie Arnold
    Nature Medicine, 2024, 30 : 6 - 9
  • [45] Autoimmune disease is the next frontier for CAR T cell therapy
    Arnold, Carrie
    NATURE MEDICINE, 2024, 30 (1) : 6 - 9
  • [46] CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy for Systemic Autoimmune Diseases
    Cingireddy, Ananya Reddy
    Flores, Brianna
    Wuthrich, John
    Cingireddy, Anirudh Reddy
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (05)
  • [47] T cell receptor gene therapy for autoimmune diseases
    Fujio, Keishi
    Okamura, Tomohisa
    Okamoto, Akiko
    Yamamoto, Kazuhiko
    AUTOIMMUNITY, PT B: NOVEL APPLICATIONS OF BASIC RESEARCH, 2007, 1110 : 222 - 232
  • [48] Regulatory T cell heterogeneity and therapy in autoimmune diseases
    Zhang, Rui
    Miao, Jinlin
    Zhu, Ping
    AUTOIMMUNITY REVIEWS, 2021, 20 (05)
  • [49] p53 further extends its reach
    Zirngibl, Katharina
    Moll, Ute M.
    ONCOIMMUNOLOGY, 2013, 2 (05):
  • [50] Blurring the boundary: The nuclear envelope extends its reach
    Stewart, Colin L.
    Roux, Kyle J.
    Burke, Brian
    SCIENCE, 2007, 318 (5855) : 1408 - 1412
12345