Channelosome and intracellular K+ channels in arrhythmia

被引：1

作者：

Fancher, Ibra ^{[1
]}

Levitan, Irena ^{[2
]}

机构：

[1] Univ Delaware, Dept Kinesiol & Appl Physiol, Newark, DE USA

[2] Univ Illinois, Dept Med, Chicago, IL 60607 USA

来源：

NATURE CARDIOVASCULAR RESEARCH | 2022年 / 1卷 / 10期

关键词：

KIR2.1; RETICULUM; MUTATIONS;

D O I：

10.1038/s44161-022-00143-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mutations in Kir2.1 resulting in defects in trafficking to the cardiomyocyte sarcolemma promote arrhythmia in Anderson-Tawil syndrome. Macias and colleagues provide a dual mechanism underlying cardiac arrhythmia that involves chaperoning of voltage-gated Na+ channels and a unique population of intracellular Kir2.1 channels that regulate Ca2+ cycling at the sarcoplasmic reticulum.

引用

页码：874 / 875

页数：2

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