Interaction of mutagenic tryptophan pyrolysate with d(CGATCG)(2): Intercalation model based on NMR experiments

被引：8

作者：

Mihara, Y

Doi, M

Inohara, T

Kawamura, M

Hamanaka, N

Ishida, T

机构：

[1] OSAKA UNIV PHARMACEUT SCI,TAKATSUKI,OSAKA 56911,JAPAN

[2] ONO PHARMACEUT CO LTD,MINASE RES INST,SHIMAMOTO,OSAKA 618,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1997年 / 240卷 / 03期

关键词：

D O I：

10.1006/bbrc.1997.7751

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The solution structure of the complex of 3-amino-1 ,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), a potent mutacarcinogen isolated from tryptophan pyrolysate, with the hexamer duplex d(CGATCG)(2), was analysed by H-1-NMR spectroscopy and molecular dynamic calculation. Trp-P-1 was intercalated between the CpG base pairings in a suitable manner to form the guanosine-Trp-P-1 adduct which corresponds to the major reactant of Trp-P-1 with DNA. (C) 1997 Academic Press.

引用

页码：803 / 806

页数：4

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