Real-time proton beam range monitoring by means of prompt-gamma detection with a collimated camera

被引：55

作者：

Roellinghoff, F. ^{[1
,2
,3
,4
,5
,6
,7
]}

Benilov, A. ^{[7
]}

Dauvergne, D. ^{[1
,2
,3
]}

Dedes, G. ^{[1
,2
,3
]}

Freud, N. ^{[4
,5
,6
]}

Janssens, G. ^{[7
]}

Krimmer, J. ^{[1
,2
,3
]}

Letang, J. M. ^{[4
,5
,6
]}

Pinto, M. ^{[1
,2
,3
]}

Prieels, D. ^{[7
]}

Ray, C. ^{[1
,2
,3
]}

Smeets, J. ^{[7
]}

Stichelbaut, F. ^{[7
]}

Testa, E. ^{[1
,2
,3
]}

机构：

[1] Univ Lyon, IPNL, F-69003 Lyon, France

[2] Univ Lyon 1, F-69622 Villeurbanne, France

[3] CNRS IN2P3, UMR 5822, F-69622 Villeurbanne, France

[4] Univ Lyon, CREATIS, F-69622 Lyon, France

[5] Univ Lyon 1, Ctr Leon Berard, France

[6] INSA Lyon, CNRS UMR 5220, INSERMU1044, Ctr Leon Berard, France

[7] Ion Beam Applicat SA, B-1348 Louvain, Belgium

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2014年 / 59卷 / 05期

关键词：

protontherapy; prompt gamma; time-of-flight; VERIFICATION; PATIENT; THERAPY;

D O I：

10.1088/0031-9155/59/5/1327

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Prompt-gamma profile was measured at WPE-Essen using 160 MeV protons impinging a movable PMMA target. A single collimated detector was used with time-of-flight (TOF) to reduce the background due to neutrons. The target entrance rise and the Bragg peak falloff retrieval precision was determined as a function of incident proton number by a fitting procedure using independent data sets. Assuming improved sensitivity of this camera design by using a greater number of detectors, retrieval precisions of 1 to 2mm (rms) are expected for a clinical pencil beam. TOF improves the contrast-to-noise ratio and the performance of the method significantly.

引用

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页码：1327 / 1338

页数：12

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