Feasibility of Salvage Re-irradiation With Stereotactic Radiotherapy for Recurrent Glioma Using CyberKnife

被引：6

作者：

Adachi, Kana ^{[1
]}

Hayashi, Kazuhiko ^{[2
,3
]}

Kagawa, Naoki ^{[4
]}

Kinoshita, Manabu ^{[4
]}

Sumida, Iori ^{[2
]}

Akino, Yuichi ^{[2
]}

Shiomi, Hiroya ^{[2
]}

Tamari, Keisuke ^{[2
]}

Suzuki, Osamu ^{[2
]}

Hirayama, Ryuichi ^{[4
]}

Kijima, Noriyuki ^{[4
]}

Isohashi, Fumiaki ^{[2
]}

Seo, Yuji ^{[2
]}

Otani, Keisuke ^{[2
]}

Kishima, Haruhiko ^{[4
]}

Ogawa, Kazuhiko ^{[2
]}

机构：

[1] Toyonaka City Hosp, Dept Radiat Oncol, Toyonaka, Osaka, Japan

[2] Osaka Univ, Grad Sch Med, Dept Radiat Oncol, 2-2 Yamadaoka, Suita, Osaka 5650871, Japan

[3] Osaka Heavy Ion Therapy Ctr, Osaka, Japan

[4] Osaka Univ, Grad Sch Med, Dept Neurosurg, Suita, Osaka, Japan

来源：

ANTICANCER RESEARCH | 2019年 / 39卷 / 06期

关键词：

Stereotactic radiotherapy; recurrent glioma; CyberKnife; re-irradiation; safety profile; PROGNOSTIC-FACTORS; RADIOSURGERY; SURVIVAL; THERAPY;

D O I：

10.21873/anticanres.13423

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aim: To evaluate the toxicity and efficacy of re-irradiation with salvage stereotactic radiotherapy (SRT) for recurrent glioma using CyberKnife. Patients and Methods: This study retrospectively investigated 35 patients with 48 recurrent grade 2-4 gliomas who received SRT between 1998 and 2011. Six patients (17.1%) had grade 2 gliomas, nine (25.7%) had grade 3 gliomas, and 20 (57.1%) had glioblastomas; all initially underwent surgery and conventional radiotherapy. The median initial and subsequent radiotherapy doses were 60 and 26 Gy, respectively. Results: After a median follow-up period of 9.0 months, the only toxicity of grade 2 or more was radiation-induced brain necrosis in four patients (11.4%). The median overall and progression-free survival periods following re-irradiation were 9.0 and 3.0 months, respectively. Univariate analysis revealed that performance status at salvage re-irradiation was a significant predictor of progression-free survival. Conclusion: Salvage re-irradiation using CyberKnife is feasible, with an acceptable toxicity profile, for patients with recurrent glioma.

引用

页码：2935 / 2940

页数：6

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