Euphorkanlide A, a Highly Modified Ingenane Diterpenoid with a C24 Appendage from Euphorbia kansuensis

被引：30

作者：

Yan, Xue-Long ^{[1
]}

Sang, Jun ^{[1
]}

Chen, Shi-Xin ^{[2
]}

Li, Wei ^{[1
]}

Tang, Gui-Hua ^{[1
]}

Gan, Li-She ^{[2
]}

Yin, Sheng ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Zhejiang, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 11期

关键词：

D O I：

10.1021/acs.orglett.9b01315

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Euphorkanlide A (1), a highly modified ingenane diterpenoid with a C-24 appendage forming an additional hexahy-droisobenzofuran-fused 19-membered macrocyclic bis-lactone ring system was isolated from the roots of Euphorbia kansuensis. Its structure was determined by extensive spectroscopic analysis and quantum-chemical calculations. Compound 1 showed significant cytotoxicities against a panel of cancer cell lines (IC50s < 5 mu M). Mechanistic study revealed that 1 could induce the generation of ROS, leading to cell cycle arrest and cell apoptosis in drug-resistant cancer cell line HCT-15/5-FU.

引用

页码：4128 / 4131

页数：4

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