From In Vitro to In Situ Tissue Engineering

被引：76
|
作者：
Sengupta, Debanti [1 ]
Waldman, Stephen D. [2 ]
Li, Song [1 ]
机构：
[1] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA
[2] Queens Univ, Dept Chem Engn, Dept Mech & Mat Engn, Kingston, ON K7L 3N6, Canada
来源：
ANNALS OF BIOMEDICAL ENGINEERING | 2014年 / 42卷 / 07期
关键词：
Biomaterials; In situ; In vitro; Tissue engineering; Translational medicine; ELECTROSPUN NANOFIBROUS SCAFFOLDS; ENDOTHELIAL GROWTH-FACTOR; STEM-CELL FATE; THERAPEUTIC ANGIOGENESIS; MACROPHAGE PHENOTYPE; BIOACTIVE HYDROGELS; CONTROLLED-RELEASE; SUSTAINED-RELEASE; ISCHEMIC DISEASE; VIVO;
D O I：
10.1007/s10439-014-1022-8
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
In vitro tissue engineering enables the fabrication of functional tissues for tissue replacement. In addition, it allows us to build useful physiological and pathological models for mechanistic studies. However, the translation of in vitro tissue engineering into clinical therapies presents a number of technical and regulatory challenges. It is possible to circumvent the complexity of developing functional tissues in vitro by taking an in situ tissue engineering approach that uses the body as a native bioreactor to regenerate tissues. This approach harnesses the innate regenerative potential of the body and directs the appropriate cells to the site of injury. This review surveys the biomaterial-, cell-, and chemical factor-based strategies to engineer tissue in vitro and in situ.
引用
收藏
页码：1537 / 1545
页数：9
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