Bcl-2 and p53 expressions in large-cell lymphoma: No correlation with survival

被引：0
|
作者：
Lee, JH
Kim, SY
Yoon, TY
Cho, KS
Yang, MH
Lee, S
Lee, SS
Ro, JY
机构：
[1] KYUNG HEE UNIV,SCH MED,DEPT INTERNAL MED,SEOUL 130702,SOUTH KOREA
[2] KYUNG HEE UNIV,SCH MED,DEPT PREVENT MED,SEOUL 130702,SOUTH KOREA
[3] KEIMYUNG UNIV,SCH MED,DEPT PATHOL,TAEGU,SOUTH KOREA
[4] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT PATHOL,HOUSTON,TX 77030
来源：
ONCOLOGY REPORTS | 1997年 / 4卷 / 02期
关键词：
bcl-2; p53; large-cell lymphoma; survival;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Bcl-2 and p53 regulate apoptosis in a see-saw fashion and are expressed abnormally in a variety of malignant tumors. We investigated the frequency and prognostic significance of both bcl-2 and p53 expression in 31 large-cell lymphomas. Immunoreaction of bcl-2 and p53 was found in 74% (23/31) and 65% (20/31) of large-cell lymphomas, respectively. Overall survival was not significantly associated with immunoreactivity for either bcl-2 or p53. Frequent association with both p53 and bcl-2 in large-cell lymphomas confirms the existence of a multistep genetic deregulation in lymphomagenesis, but their clinical significance remains to be elucidated in a larger study.
引用
收藏
页码：413 / 417
页数：5
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