Characterization of the human germ cell nuclear factor gene

被引：30
|
作者：
Susens, U [1 ]
Borgmeyer, U [1 ]
机构：
[1] UNIV HAMBURG,ZENTRUM MOL NEUROBIOL,D-20251 HAMBURG,GERMANY
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1996年 / 1309卷 / 03期
关键词：
germ cell nuclear factor; nuclear receptor superfamily; expression; testis; neuronal;
D O I：
10.1016/S0167-4781(96)00157-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A cDNA clone encoding the germ cell nuclear factor, GCNF, a member of the nuclear receptor superfamily has been isolated from the human embryonal carcinoma cell line NT2/D1. Sequencing of this clone reveals an open reading frame encoding a 476 amino acid protein. A comparison of the amino acid sequence of the human GCNF with its mouse homologue shows only six amino acid exchanges in the whole protein and a deletion in the amino-terminal region. Northern blot analysis demonstrates that the expression in the testis is conserved.
引用
收藏
页码：179 / 182
页数：4
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