Immunological Backbone of Uveal Melanoma: Is There a Rationale for Immunotherapy?

被引：38

作者：

Rossi, Ernesto ^{[1
]}

Schinzari, Giovanni ^{[1
,2
]}

Zizzari, Ilaria Grazia ^{[3
]}

Maiorano, Brigida Anna ^{[1
]}

Pagliara, Monica Maria ^{[4
]}

Sammarco, Maria Grazia ^{[4
]}

Fiorentino, Vincenzo ^{[5
]}

Petrone, Gianluigi ^{[5
]}

Cassano, Alessandra ^{[1
,2
]}

Rindi, Guido ^{[5
]}

Bria, Emilio ^{[1
,2
]}

Blasi, Maria Antonietta ^{[4
]}

Nuti, Marianna ^{[3
]}

Tortora, Giampaolo ^{[1
,2
]}

机构：

[1] Fdn Policlin Univ, A Gemelli IRCCS, Med Oncol, I-00168 Rome, Italy

[2] Univ Cattolica Sacro Cuore, Med Oncol, I-00168 Rome, Italy

[3] Sapienza Univ, Dept Expt Med, Lab Tumor Immunol & Cell Therapy, Policlin Umberto 1, I-00162 Rome, Italy

[4] Fdn Policlin Univ, A Gemelli IRCCS, Ophtalmol, I-00168 Rome, Italy

[5] Fdn Policlin Univ, A Gemelli IRCCS, Pathol, I-00168 Rome, Italy

来源：

CANCERS | 2019年 / 11卷 / 08期

关键词：

immunotherapy; uveal melanoma; checkpoint inhibitors; PD-L1; nivolumab; pembrolizumab; ipilimumab; IDO; TUMOR-INFILTRATING LYMPHOCYTES; MIGRATION-INHIBITORY FACTOR; CANDIDATE PROTEINS GP100; ANTIGEN EXPRESSION; ADOPTIVE TRANSFER; HLA EXPRESSION; CELL-ACTIVITY; MONOSOMY; CLASS-I; IPILIMUMAB;

D O I：

10.3390/cancers11081055

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features of mUM were reviewed in order to understand if immunotherapy could still play a role for this disease.

引用

页数：12

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