Synthesis, Characterization, Antibacterial and Anti-Inflammatory Activities of Enoxacin Metal Complexes

The present work comprises the synthesis of enoxacin (Heno) complexes with various transition metals. Two types of complexes [M(eno)(2)(H2O)(2)](3)H2O(M = Cu-II, Ni-II or Mn-II) and [M(eno)(H2O)(2)]Cl center dot 4H(2)O (M = Fe-III) were obtained. The complexes were characterized by different physicochemical, spectroscopic, and elemental analysis. Results suggest that enoxacin interacts with the metals as a monoanionic bidentate ligand. These complexes were also tested for their antibacterial activity against eleven (11) different microorganisms, and the results were compared with the parent drug. Moreover all the metal complexes were also tested for their ability to scavenge reactive oxygen species where by Mn-II and Cu-II complexes exhibited potential to mediate anti-inflammatory response. Copyright (C) 2009 Saeed Arayne et al.