Identification of Anti-prostate Cancer Targets for Resveratrol: an Inverse Screening Approach

Chemoprevention of cancer through phytochemicals has become a powerful weapon against cancer. The intake of bioactive components in our diet reduces the risk of cancer. Resveratrol has proved as one of the promising phytochemical derived from grape skin against cancer. In the present study the role of resveratrol in prostate cancer prevention was taken into consideration. The putative therapeutic targets for resveratrol were obtained from the PharmMapper Server with their fit scores. The targets obtained were classified as antiprostate cancer, anti-inflammatory, Signal transducing modulators, anti-oxidant, anti-proliferative and anti-angiogenesis based on their therapeutic action using TTD (Therapeutic Target Database) and PDTD (Potential Drug Target Database). Our component resveratrol showed to be an important molecule which can be helpful in the drug discovery against prostate cancer.