Sexually dimorphic gene expression in the chick brain before gonadal differentiation

被引：32

作者：

Lee, S. I. ^{[1
,2
]}

Lee, W. K. ^{[3
]}

Shin, J. H. ^{[4
]}

Han, B. K. ^{[4
]}

Moon, S. ^{[1
,2
]}

Cho, S. ^{[5
]}

Park, T. ^{[5
]}

Kim, H. ^{[1
,2
]}

Han, J. Y. ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Dept Agr Biotechnol, Seoul 151921, South Korea

[2] Seoul Natl Univ, Res Inst Agr & Life Sci, Seoul 151921, South Korea

[3] Hankook Life Sci Inst Co Ltd, DNA Lab, Seoul 405207, South Korea

[4] Optifarm Solut Inc, Avicore Biotechnol Inst, Gyeonggi Do 435050, South Korea

[5] Seoul Natl Univ, Dept Stat, Seoul 151747, South Korea

来源：

POULTRY SCIENCE | 2009年 / 88卷 / 05期

关键词：

chicken; sexual brain differentiation; differentially expressed gene; quantitative real-time polymerase chain reaction; SEX DETERMINATION; ZEBRA FINCHES; PROBE LEVEL; CHROMOSOME; BEHAVIOR; EMBRYOS; DUPLICATION; SPINDLIN; PROTEIN; CELLS;

D O I：

10.3382/ps.2008-00197

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Biological bases for sexual differences in the brain exist in a wide range of vertebrate species, including chickens. Recently, the dogma of hormonal dependence for the sexual differentiation of the brain has been challenged. We examined whether sexually dimorphic gene expression in the brain precedes gonadal differentiation. Using the Affymetrix GeneChip Chicken Genome Array, we identified 42 female- and 167 male-enhanced genes that were differentially expressed in sex-specific brains from stage 29 chicken embryos. To confirm the efficacy of the microarray, and to investigate the stage-specific expression patterns of the identified genes, we used quantitative real-time PCR analysis. Our real-time PCR results for the differentially expressed genes agreed well with our microarray results. Thus, we postulate that these genes have potential roles in the sexual differentiation of neural function and development in chickens.

引用

页码：1003 / 1015

页数：13

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