Adipokines: a link between obesity and dementia?

被引：201

作者：

Kiliaan, Amanda J. ^{[1
]}

Arnoldussen, Ilse A. C. ^{[1
]}

Gustafson, Deborah R. ^{[2
,3
,4
]}

机构：

[1] Radboud Univ Nijmegen, Dept Anat, Donders Inst Brain Cognit & Behav, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[2] Suny Downstate Med Ctr, Dept Neurol, Brooklyn, NY 11203 USA

[3] Sahlgrenska Acad Univ Gothenburg, Inst Neurosci & Physiol, Sect Psychiat & Neurochem, Neuropsychiat Epidemiol Unit, Gothenburg, Sweden

[4] UMS 011 Inserm Versailles, St Quentin en Yvelines, France

来源：

LANCET NEUROLOGY | 2014年 / 13卷 / 09期

基金：

瑞典研究理事会;

关键词：

HEPATOCYTE GROWTH-FACTOR; PLASMINOGEN-ACTIVATOR INHIBITOR-1; BODY-MASS INDEX; MILD COGNITIVE IMPAIRMENT; TRAUMATIC BRAIN-INJURY; INCIDENT ALZHEIMER-DISEASE; HUMAN CEREBROSPINAL-FLUID; FOCAL CEREBRAL-ISCHEMIA; VASCULAR RISK-FACTORS; ADIPOSE-TISSUE;

D O I：

10.1016/S1474-4422(14)70085-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Being overweight or obese, as measured with body-mass index or central adiposity (waist circumference), and the trajectory of body-mass index over the life course have been associated with brain atrophy, white matter changes, disturbances of blood brain barrier integrity, and risk of all-cause late-onset dementia and Alzheimer's disease. This observation leads us to question what it is about body-mass index that is associated with health of the brain and dementia risk. If high body-mass index and central adiposity represent an increase in adipose tissue, then the endocrine function of adipose tissue, mediated by adipose tissue hormones and adipokines, could be a due to mechanisms that underlie the association with dementia and Alzheimer's disease. Hundreds of adipoldnes have been identified, creating a complexity that is a challenge to simplify. Nonetheless, adipokines are being investigated in association with clinical dementia outcomes, and with imaging-based measures of brain volume, structure, and function in human beings and in predinical models of clinical dementia.

引用

页码：913 / 923

页数：11

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