Synthesis and X-ray structure of platinum(II), palladium(II) and copper(II) complexes with pyridine-pyrazole ligands: Influence of ligands' structure on cytotoxic activity

被引：52
|
作者：
Budzisz, Elzbieta [1 ]
Miernicka, Magdalena [1 ]
Lorenz, Ingo-Peter [2 ]
Mayer, Peter [2 ]
Krajewska, Urszula [3 ]
Rozalski, Marek [3 ]
机构：
[1] Med Univ Lodz, Fac Pharm, Dept Cosmet Raw Mat Chem, PL-90151 Lodz, Poland
[2] Univ Munich, Dept Chem & Biochem, D-81377 Munich, Germany
[3] Med Univ Lodz, Fac Pharm, Dept Pharmaceut Biochem, PL-90151 Lodz, Poland
来源：
POLYHEDRON | 2009年 / 28卷 / 03期
关键词：
Synthesis; X-ray structure; Cytotoxic effect; Pyrazole ligands; Platinum(II); Palladium(II); Copper(II)); complexes; 9-Methylguanine; CRYSTAL-STRUCTURES; DICOPPER(II) COMPLEX; COLUMNAR MESOPHASES; BIOLOGICAL-ACTIVITY; MAGNETIC-PROPERTIES; ANTITUMOR-ACTIVITY; CHROMONE SERIES; DERIVATIVES; COORDINATION; 1,10-PHENANTHROLINE;
D O I：
10.1016/j.poly.2008.12.013
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The new pyrazole ligand 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridylo)-1H-pyrazole-4-phosphonic acid dimethyl ester (2a) has been used to obtain a series of platinum(II), palladium(II) and copper(II) complexes (3a-7a) as potential anticancer compounds. The molecular structures of the platinum(II) and copper(II) complexes 3a and 6a have been determined by X-ray crystallography. The cytotoxicity of the phosphonic ligand 2a and its carboxylic analog 2b as well as their complexes has been evaluated on leukemia and melanoma cell lines. Copper(II) complexes were found to be more efficient in the induction of melanoma cell death than the platinum(II) or palladium(H) complexes. Cytotoxic effectiveness of compound 7b against melanoma WM-115 cells was two times better than that of cisplatin. The reaction of compound 5b with 9-methylguanine has been studied. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：637 / 645
页数：9
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