Analysis of medaka cytochrome P450 3A homotropic and heterotropic cooperativity

被引：12
|
作者：
Kullman, SW [1 ]
Kashiwada, S [1 ]
Hinton, DE [1 ]
机构：
[1] Duke Univ, Nicholas Sch Environm & Earth SCi, Durham, NC 27708 USA
来源：
MARINE ENVIRONMENTAL RESEARCH | 2004年 / 58卷 / 2-5期
关键词：
D O I：
10.1016/j.marenvres.2004.03.030
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
We have previously demonstrated that medaka CYP3A is associated with metabolism of several endobiotics including steroids and bile acids. In this study, we demonstrate that medaka CYP3A catalysis exhibits unusual kinetic behaviors consistent with allosteric interaction which cannot be described by hyperbolic kinetic models. Using 7-benzyloxy-4-(trifluoromethyl)-coumarin (BFC) and nonylphenol as CYP3A substrates, we describe both homotropic and heterotropic cooperative interactions. Given the role of CYP3A in maintaining the homeostatic balance for numerous endobiotics, enzymatic activation/inhibition by endocrine disruptors (EDCs) represents a putative (non-genomic) mechanism for endocrine disruption. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：469 / 473
页数：5
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