Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling

被引：7
|
作者：
Xu, Chaoyang [1 ,2 ]
Xie, Shuduo [3 ]
Song, Chunjiao [2 ]
Huang, Liming [1 ]
Jiang, Zhinong [4 ]
机构：
[1] Zhejiang Univ, Shaoxing Hosp, Shaoxing Peoples Hosp, Dept Breast & Thyroid Surg, Shaoxing, Peoples R China
[2] Zhejiang Univ, Shaoxing Peoples Hosp, Dept Med Res Ctr, Shaoxing Hosp, Hangzhou, Zhejiang, Peoples R China
[3] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Oncol Surg, Hangzhou 310003, Zhejiang, Peoples R China
[4] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Pathol, Hangzhou 310003, Zhejiang, Peoples R China
来源：
HEPATO-GASTROENTEROLOGY | 2014年 / 61卷 / 132期
基金：
中国国家自然科学基金;
关键词：
Lin28; Chemoresistance; Cancer; miRNA; ADVANCED BREAST-CANCER; STEM-CELLS; MULTIDRUG-RESISTANCE; DRUG-RESISTANCE; P-GLYCOPROTEIN; EXPRESSION; PROTEINS; MICRORNA;
D O I：
10.5754/hge14028
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Chemotherapy resistance is one of the major obstacles limiting the success of cancer drug treatment. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to P-Glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. Lin28 is a highly conserved RNA-binding protein, it consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs. In previous preclinical and clinical studies, positive Lin28 expression in cancer cells was correlated with decreased sensitivity to chemotherapy. And Lin28 could mediate cancer chemotherapy resistance via regulation of miR107 and Let-7 miRNA. This article reviews current knowledge on predictive value of Lin28 in response to chemotherapy. Better understanding of its role may facilitate patient's selection of therapeutio regimen and lead to optimal clinical outcome.
引用
收藏
页码：1138 / 1141
页数：4
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