Photodynamic inactivation of bioluminescent Escherichia coli by neutral and cationic pyrrolidine-fused chlorins and isobacteriochlorins

被引：40
|
作者：
Mesquita, Mariana Q. [1 ,2 ]
Menezes, Jose C. J. M. D. S. [1 ,2 ]
Neves, Maria G. P. M. S. [1 ,2 ]
Tome, Augusto C. [1 ,2 ]
Cavaleiro, Jose A. S. [1 ,2 ]
Cunha, Angela [3 ,4 ]
Almeida, Adelaide [3 ,4 ]
Hackbarth, Steffen [3 ,4 ,5 ]
Roeder, Beate [5 ]
Faustino, M. Amparo F. [1 ,2 ]
机构：
[1] Univ Aveiro, Dept Chem, P-3810193 Aveiro, Portugal
[2] Univ Aveiro, QOPNA, P-3810193 Aveiro, Portugal
[3] Univ Aveiro, Dept Biol, P-3810193 Aveiro, Portugal
[4] Univ Aveiro, CESAM, P-3810193 Aveiro, Portugal
[5] Humboldt Univ, Inst Phys, D-12489 Berlin, Germany
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2014年 / 24卷 / 03期
关键词：
Chlorin; Isobacteriochlorin; Photodynamic inactivation; Escherichia coli; Cationic photosensitizers; ANTIBACTERIAL ACTIVITY; PORPHYRIN; THERAPY; BACTERIA; TETRAARYLPORPHYRINS; PHOTOINACTIVATION; PHOTOSENSITIZERS; RESISTANCE; VIABILITY; RECOVERY;
D O I：
10.1016/j.bmcl.2013.12.097
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Photodynamic inactivation of bioluminescent Escherichia coli in the presence of cationic chlorin and isobacteriochlorin photosensitizers (PSs) obtained from 5,10,15,20-tetrakis(pentafluorophenyl)-porphyrin is described. The spectroscopic data for the neutral and cationic derivatives and their photophysical characterizations, especially fluorescence and singlet oxygen generation capacity are also reported. The results show that there is a direct relation between the inactivation efficiency and the increasing number of charges on the molecules. The combined effect of higher wavelength absorption and number of positive charges on the PS shows a 6.1 log reduction during the inactivation process. Overall this study shows that the cationic isobacteriochlorin has high potential to be used as PS for the inactivation of Gram (-) bacteria. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：808 / 812
页数：5
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