Synthesis of phenanthridinones using Cu- or Pd-mediated C-N bond formation

被引：11
|
作者：
Nealmongkol, Prattya [1 ]
Calmes, Jordan [2 ]
Ruchirawat, Somsak [1 ,2 ,3 ]
Thasana, Nopporn [1 ,2 ,3 ]
机构：
[1] Chulabhorn Grad Inst, Chem Biol Program, Kamphaeng Phet 6, Bangkok 10210, Thailand
[2] Chulabhorn Res Inst, Med Chem Lab, Kamphaeng Phet 6, Bangkok 6, Thailand
[3] Minist Educ, CHE, Ctr Excellence Environm Hlth & Toxicol, Bangkok 10210, Thailand
来源：
TETRAHEDRON | 2017年 / 73卷 / 06期
关键词：
Copper; Palladium; C-N bond formation; Phenanthridinone; Lactam; BIARYL SYNTHESIS; H ACTIVATION; AROMATIC CARBOXYLATES; LAMELLARIN ALKALOIDS; EFFICIENT SYNTHESIS; COUPLING REACTION; ACIDS; ANNULATION; AMIDATION; AMINATION;
D O I：
10.1016/j.tet.2016.12.051
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The chemoselective synthesis of phenanthridinones was studied using copper(I)-and palladium(II)-catalyzed C-N bond formation with various bases, ligands, and solvents. Phenanthridinones were obtained from 2-halobiarylcarboxylates and amines in a one-pot reaction. The phenanthridinones and heterocyclic-fused lactam derivatives were accomplished using developed methods. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：735 / 741
页数：7
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