Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

被引：14

作者：

Higuchi, Hitomi ^{[1
]}

Yamamoto, Shota ^{[1
]}

Ushio, Soichiro ^{[1
]}

Kawashiri, Takehiro ^{[1
]}

Egashira, Nobuaki ^{[1
]}

机构：

[1] Kyushu Univ Hosp, Dept Pharm, Fukuoka 8128582, Japan

来源：

JOURNAL OF PHARMACOLOGICAL SCIENCES | 2015年 / 129卷 / 03期

关键词：

Goshajinkigan; Bortezomib; Peripheral neuropathy; INDUCED PERIPHERAL NEUROPATHY; PLACEBO-CONTROLLED TRIAL; GOSHA-JINKI-GAN; DIABETIC-NEUROPATHY; DOUBLE-BLIND; SPINAL-CORD; ANALGESIA; NEUROTOXICITY; MEDICINE; TRAMADOL;

D O I：

10.1016/j.jphs.2015.09.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 mu g/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia. (C) 2015 The Authors. Production and hosting by Elsevier B. V. on behalf of Japanese Pharmacological Society.

引用

页码：196 / 199

页数：4

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