Two new alkaloid metabolites produced by endophytic fungus Stagonosporopsis oculihominis isolated from Dendrobium huoshanense

被引：16
|
作者：
Yu, Yang [1 ]
Ma, Bing-ji [2 ]
Liu, Jin-song [1 ]
Yue, Jing-yi [1 ]
Chen, He-ping [3 ]
Liang, Yi-min [1 ]
Zhou, Zhong-yu [4 ]
Wang, Guo-kai [1 ]
Wang, Gang [1 ]
机构：
[1] Anhui Univ Chinese Med, Sch Pharm, Anhui Key Lab Modern Chinese Mat Med, Hefei 230031, Peoples R China
[2] Henan Agr Univ, Dept Tradit Chinese Med, Zhengzhou 450002, Peoples R China
[3] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West C, Kunming 650201, Peoples R China
[4] Chinese Acad Sci, Guang Dong Prov Key Lab Appl Bot, South China Bot Garden, Guangzhou 510650, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2017年 / 19卷
关键词：
Alkaloid; Endophytic fungus; Stagonosporopsis oculihominis; Cytotoxicity; TETRACYCLIC TRITERPENOIDS; FUSARIUM SP; BACTERIUM;
D O I：
10.1016/j.phytol.2017.02.006
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Two new alkaloids (1-2), together with six known compounds (3-8), were isolated from cultures of the endophytic fungus Stagonosporopsis oculihominis. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRMS analyses. The absolute configurations of 1 was determined by the comparison of experimental and theoretical electronic circular dichroism spectra. The new compounds were investigated for their cytotoxicity against five human cancer cell lines. (C) 2017 Phytochemical Society of Europe. Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：266 / 270
页数：5
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