New parameters derived from tablet compression curves .1. Force-time curve

A great number of new parameters derived from tablet force-time curves ape introduced. The crushing strength and friability of tablets were measured, and the dependence between the calculated compression parameters and the two tablet properties was studied. Tablets were made with an instrumented eccentric tablet machine using three different compression forces and three different compression speeds. The testing material was alpha-lactose monohydrate. This seems to be a limitation in this study, but OUT main purpose was to introduce these new compression parameters. The results showed that the suggested parameters described clearly different patterns of material behavior. We suggest that, especially together, these parameters may be used in the prediction of compression characteristics of different material.