DNA cleavage properties and synthesis of metallophthalocyanines with 5-methyl-[1,2,4] triazolo [1, 5-a] pyrimidin-7-oxy substituents

被引：5
|
作者：
Agirtas, M. Salih [1 ]
Ondes, M. Yusuf [1 ]
Ozdemir, Sadin [2 ]
Okumus, Veysi [2 ]
机构：
[1] Yuzuncu Yil Univ, Dept Chem, Fac Sci, TR-65080 Van, Turkey
[2] Siirt Univ, Fac Arts & Sci, Dept Biol, Siirt, Turkey
来源：
INORGANIC AND NANO-METAL CHEMISTRY | 2017年 / 47卷 / 07期
关键词：
Phthalocyanine; synthesis; electronic structure; aggregation; DNA cleavage; AGGREGATION BEHAVIOR; METAL-FREE; PHTHALOCYANINES; BINDING; ANTIOXIDANT; COPPER(II); COMPLEXES; LIGAND;
D O I：
10.1080/24701556.2017.1284086
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The aim of the present study is to perform synthesis of novel metallophthalocyanines (pcs) with high solubility. The synthesis and characterization of 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted zinc, magnesium, and cobalt pcs are reported. These compounds have been characterized using electronic absorption, nuclear magnetic resonance spectroscopy, infrared, elemental analysis and mass spectra. The aggregation investigations carried out in different concentrations indicate that 5-methyl-[1, 2, 4] triazolo [1, 5-a] pyrimidin-7-yloxy-substituted pc complexes do not have any aggregation behavior for the concentration range of 1 x 10(-5) -1 x 10(-6) M in THF. DPPH radical scavenging activity, metal chelating activity, and reducing power of the compounds were evaluated. The DNA gel electrophoresis studies revealed that new phthalonitrile and its metallophthalocyanine compounds cleavaged plasmid DNA (pBR322). Additionally, the ground-state geometries of the complexes were optimized using density functional theory methods at B3LYP/6-31G (d, p) level in order to obtain information about the 3D geometries and electronic structure.
引用
收藏
页码：1097 / 1102
页数：6
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