Estimating the age of the common ancestor of a sample of DNA sequences

被引:85
|
作者
Fu, YX
Li, WH
机构
[1] Human Genetics Center, University of Texas, Houston, TX
[2] Human Genetics Center, School of Public Health, University of Texas at Houston, Houston, TX 77225
关键词
common ancestor; age estimation; coalescent approach; Y chromosome; Alu sequence;
D O I
10.1093/oxfordjournals.molbev.a025753
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We present a simple Monte Carlo method for estimating the age of the most recent common ancestor (MRCA) of a sample of DNA sequences. We show that Templeton's (1993) estimator of the age of the MRCA based on the maximum number of nucleotide differences between two sequences in a sample is inaccurate, and we demonstrate the new method by reanalyzing a sample of DNA sequences from human Y chromosomes and a sample of human Alu sequences.
引用
收藏
页码:195 / 199
页数:5
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