Release of Insulin from Calcium Carbonate Microspheres with and without Layer-by-Layer Thin Coatings

被引：13
|
作者：
Sato, Katsuhiko [1 ]
Seno, Masaru [1 ]
Anzai, Jun-Ichi [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Aoba Ku, Sendai, Miyagi 9808578, Japan
来源：
POLYMERS | 2014年 / 6卷 / 08期
基金：
日本学术振兴会;
关键词：
microsphere; polymer coating; calcium carbonate; insulin delivery; layer-by-layer film; controlled release; POROUS CACO3 MICROPARTICLES; ENCAPSULATION; FILMS; MICROCAPSULES; STABILITY; TRANSITION; VATERITE; DELIVERY; ENZYME;
D O I：
10.3390/polym6082157
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
The release of insulin from insulin-containing CaCO3 microspheres was investigated. The microspheres were prepared by mixing aqueous solutions of CaCl2 and Na2CO3 in the presence of insulin. The surface of the insulin-containing CaCO3 microspheres was coated with a layer-by-layer thin film consisting of poly(allylamine hydrochloride) and poly(styrene sulfonate) to regulate the release kinetics of insulin. The release rate of insulin from the coated CaCO3 microspheres was significantly suppressed compared with that of uncoated CaCO3 microspheres, and depended on the thickness of the films. Rhombohedral calcite crystals of CaCO3 formed from the microspheres during the release of insulin, suggesting that the CaCO3 microspheres dissolved and recrystallized during the release of insulin.
引用
收藏
页码：2157 / 2165
页数：9
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