Metastasis Organotropism: Redefining the Congenial Soil

被引：235
|
作者：
Gao, Yang [1 ,2 ,3 ]
Bado, Igor [1 ,2 ,3 ]
Wang, Hai [1 ,2 ,3 ]
Zhang, Weijie [1 ,2 ,3 ]
Rosen, Jeffrey M. [2 ,3 ]
Zhang, Xiang H-F [1 ,2 ,3 ,4 ]
机构：
[1] Baylor Coll Med, Lester & Sue Smith Breast Ctr, One Baylor Plaza, Houston, TX 77030 USA
[2] Baylor Coll Med, Dan L Duncan Canc Ctr, One Baylor Plaza, Houston, TX 77030 USA
[3] Baylor Coll Med, Dept Mol & Cellular Biol, One Baylor Plaza, Houston, TX 77030 USA
[4] Baylor Coll Med, McNair Med Inst, One Baylor Plaza, Houston, TX 77030 USA
来源：
DEVELOPMENTAL CELL | 2019年 / 49卷 / 03期
关键词：
BREAST-CANCER CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; REPROGRAMS GLUCOSE-METABOLISM; BONE METASTASIS; BRAIN-METASTASIS; OVARIAN-CANCER; PROSTATE-CANCER; PREMETASTATIC NICHE; LUNG METASTASIS; LIVER METASTASIS;
D O I：
10.1016/j.devcel.2019.04.012
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Metastasis is the most devastating stage of cancer progression and causes the majority of cancer-related deaths. Clinical observations suggest that most cancers metastasize to specific organs, a process known as 'organotropism.'' Elucidating the underlying mechanisms may help identify targets and treatment strategies to benefit patients. This review summarizes recent findings on tumor-intrinsic properties and their interaction with unique features of host organs, which together determine organ-specific metastatic behaviors. Emerging insights related to the roles of metabolic changes, the immune landscapes of target organs, and variation in epithelial-mesenchymal transitions open avenues for future studies of metastasis organotropism.
引用
收藏
页码：375 / 391
页数：17
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