Twelve formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus robusta

被引：26

作者：

Shang, Zhi-Chun ^{[1
,2
]}

Han, Chao ^{[1
,2
]}

Xu, Jia-Li ^{[1
,2
]}

Liu, Rui-Huan ^{[1
,2
]}

Yin, Yong ^{[1
,2
]}

Wang, Xiao-Bing ^{[1
,2
]}

Yang, Ming-Hua ^{[1
,2
]}

Kong, Ling-Yi ^{[1
,2
]}

机构：

[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Jiangsu Key Lab Bioact Nat Prod Res, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China

来源：

PHYTOCHEMISTRY | 2019年 / 163卷

基金：

中国国家自然科学基金;

关键词：

Eucalyptus robusta Smith; Myrtaceae; Phloroglucinol meroterpenoids; Antifungal; CIRCULAR-DICHROISM; FRUITS; SESQUITERPENOIDS;

D O I：

10.1016/j.phytochem.2019.04.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Twelve formyl phloroglucinol meroterpenoids (FPMs) were isolated from the leaves of Eucalyptus robusta Smith. Their structures were elucidated via spectroscopic data analysis, the circular dichroism (CD) exciton chirality method, Rh-2(OCOCF3)(4)-induced CD experiments, and application of the Snatzke chirality rules. Eucalrobusones Q, S, and X are the first FPMs that have been identified in which the C-7' of phloroglucinol is linked to the C-15 of cadinane, the C-4 of cubebane, and the C-8 of menthane, respectively. (+)-Eucalrobusone X exhibited the most potent antifungal ability against Candida albicans with a MIC50 value of 10.78 mu g/mL, and eucalrobusone U exhibited the greatest anti-C. glabrata activity with MIC50 value of 1.53 mu g/mL.

引用

页码：111 / 117

页数：7

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