Neurotransmitter-related genes and antipsychotic response: pharmacogenetics meets psychiatric treatment

被引：17

作者：

Arranz, MJ ^{[1
]}

Kerwin, RW ^{[1
]}

机构：

[1] Inst Psychiat, Dept Psychol Med, Sect Clin Neuropharmacol, London SE5 8AF, England

来源：

ANNALS OF MEDICINE | 2000年 / 32卷 / 02期

关键词：

antipsychotic response; neuroreceptors; pharmacogenetics;

D O I：

10.3109/07853890009011762

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pharmacogenetic research into neurotransmitter-related genes is helping to unravel genetic factors that determine antipsychotic response, Several genetic mutations in neurotransmitter receptors targeted by antipsychotic drugs have been found to be related to clinical response, Modern molecular genetic techniques will facilitate the identification of those mutations that determine treatment response. Future psychiatric prescription will include the genetic characterization of neurotransmitter receptors for the selection of the most beneficial drug according to the individual's pharmacogenetic profile.

引用

页码：128 / 133

页数：6

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